May 02, · Treating middle ear infections. You may be prescribed antibiotics. Some antibiotics may be taken orally. Others can be applied directly to the site of the infection with ear drops. Medications for Author: James Roland. Aug 24, · What home remedies relieve ear pain and cure ear infections? Over the counter pain relievers, for example, acetaminophen (Tylenol and others) and ibuprofen (Advil). Those over 18 years of age can also For ear pain associated with a middle ear infection without an eardrum perforation, warm.